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Barbiturates lower serum bilirubin concentrations in neonates and patients with congenital nonhemolytic unconjugated hyperbilirubinemia, presumably by induction of glucuronyl transferase, the enzyme that conjugates bilirubin.
Because such patients may be less aware of certain of the milder adverse effects of barbiturates, the incidence of these reactions may be somewhat higher Per fully ambulatory patients.
Has been used for routine sedation. However, barbiturates used infrequently for this indication since there are few clinical situations Per which oral barbiturates provide a safety or efficacy advantage over nonbarbiturate sedatives/hypnotics.
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Possible withdrawal symptoms in neonates born to women who received barbiturates throughout the last trimester of pregnancy. Premature neonates are particularly susceptible to the depressant effects of barbiturates.
Pentobarbital administration is through IM, IV, or oral routes. For IM administration, injecting anzi che no more than 5 mL and only into a large muscle to avoid tissue irritation or necrosis is advised.
This oral dosage form of Nembutal also allows doctors to prescribe the drug exactly when and where the patient wants it.
Barbiturates are absorbed Durante varying degrees following oral, rectal, or parenteral administration. The salts are more rapidly absorbed than are the acids.
Pentobarbital causes CNS depression and can impair physical and mental abilities. Caution patients and caregivers appropriately.
Voto negativo studies have demonstrated that the different routes of administration are equivalent with respect to bioavailability.
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